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Prof. Dr.-Ing. Christiane Thielemann

Projekte

Publikationen

  • Caroline Lourenco Alves, Tiago Martinelli, Loriz Francisco Sallum, Francisco Aparecido Rodrigues, Thaise G. L. de O. Toutain, Joel Augusto Moura Porto, Christiane Thielemann, Patricia Maria de Carvalho Aguiar, Michael Möckel, 2024. Multiclass classification of Autism Spectrum Disorder, attention deficit hyperactivity disorder, and typically developed individuals using fMRI functional connectivity analysis. In: PLoS One.
  • Mark Pottek, Soren Soerensen, Wolfgang Knoll, Steffen Howitz, Christiane Thielemann, 2006. Cell-based Microfluidic System for Drug Screening Applications. In: MST news, 2006. (1), S. 38 — 39.
  • Christoph Nick, Christiane Thielemann, 2014. Are Carbon Nanotube Microelectrodes Manufactured from Dispersion Stable Enough for Neural Interfaces? In: BioNanoScience. 2014(4 / 3), S. 216 — 225.
  • Florian Emmerich 2020. Eigenschaften und Anwendungen von Dünnschicht-Elektretmaterialien.
  • Andreas Daus, Christiane Thielemann, 2010. Spheroids on microelectrode arrays: A highly sensitive system for biosensing applications. In: European Journal of cell biology. (89 Sonderheft 1), S. 67 — 68.
  • Tim Köhler, Maximilian Wölfel, Ulrich Bochtler, Christiane Thielemann, 2016. TETRA specific long-term exposure of neuronal in vitro networks.
  • Andreas Daus, Matthias Hasenkopf, Christiane Thielemann, 2009. Novel 3D cell culture systems for electromagnetic exposure studies.
  • Andreas Daus, Michael Goldhammer, Ulrich Bochtler, Christiane Thielemann, 2009. Electromagnetic exposition of neuronal networks in vitro.
  • Margot Mayer, Sylvia Ritter, Christiane Thielemann, 2013. Electrophysiological Effects of Ionising Radiation on Cortical Rat Neurons in vitro.
  • Frederik Steger, Sylvia Ritter, Andreas Daus, Johannes Frieß, Christiane Thielemann, 2011. Analysis of electrophysiological characteristics of cardiomyocytes following radiation exposure.
  • Johannes Frieß, Anja Heselich, Sylvia Ritter, Christiane Thielemann, 2013. Electrophysiological characteristics of cardiomyocytes after heavy ion exposure. Darmstadt, Deutschland
  • Johannes Frieß, Anja Heselich, Sylvia Ritter, Paul Layer, Christiane Thielemann, 2013. Effect of X-rays and titanium ions on cardiomyocyte cultures.
  • Christoph Nick, Sebastian Quednau, Reza Sarwar, Christiane Thielemann, Helmut Schlaak, 2013. Gold-Nanodrähte auf Mikroelektroden zur extrazellulären Ableitung elektrogener Zellen. Aachen, Deutschland: VDE Verlag.
  • Johannes Frieß, Anja Heselich, Sylvia Ritter, Andreas Daus, Paul Layer, Christiane Thielemann, 2012. Electrophysiological Effects of Heavy Ion Irradiation on Cardiomyocytes.
  • Christoph Nick, Thorsten Heinlein, Jörg Schneider, Christiane Thielemann, 2012. 3D Carbon Nanotube Electrodes for Sensing of Neural Activity. Cancun, Mexiko
  • Berit Silke Körbitzer 2019. Untersuchung funktioneller Schnittstellen zwischen Graphen und neuronalen Zellen.
  • Andreas Daus, Michael Goldhammer, Paul Layer, Christiane Thielemann, 2011. Electromagnetic exposure of scaffold-free three-dimensional cell culture systems. In: Bioelectromagnetics. 32(5), S. 351 — 359. ISSN 1521-186X.
  • Michael Goldhammer, Andreas Daus, Christiane Thielemann, Ulrich Bochtler, 2009. Flexible measurement setup for electromagnetic exposition of biological samples.
  • Markus Pax, Janosch Rieger, Christiane Thielemann, Diethelm Johannsmann, 2005. Cell-Based Biosensors for Drug Screening: Detection of the Beating Rate of Cardiac Myocytes with a Quartz crystal Resonator. In: Analyst. S. 1451 — 1458.
  • Robert Bestel, Andreas Daus, Christiane Thielemann, 2012. A novel automated spike sorting algorithm with adaptable feature extraction. In: Journal of Neuroscience Methods. 211(1), S. 168 — 178.
  • Berit Silke Körbitzer, Peter Krauß, Christoph Nick, Jörg Schneider, Christiane Thielemann, 2015. Graphene electrodes for recording and stimulation of neural cells. Barcelona, Spanien
  • Florian Emmerich, Christiane Thielemann, 2014. Direct Visualisation of Stored Charges in PECVD ONO-Layers by Kelvin-Probe-Force-Microscopy. Baltimore, USA
  • Frank Arnheiter, Tim Asmus, Thomas Loose, Karlheinz Wienand, Christiane Thielemann, 2009. Metal-nanosensor for the detection of biomolecules. ISBN 978-3-8007-3155-8.
  • Christoph Nick, Sandeep Yadav, Ravi Joshi, Jörg Schneider, Christiane Thielemann, 2014. Growth of Cortical Neurons Grown on Randomly Oriented and Vertically Aligned Dense Carbon Nanotube Networks. In: Beilstein Journal of Nanotechnology. S. 1575 — 1579.
  • Christoph Nick, Helmut Schlaak, Christiane Thielemann, 2014. PEDOT:PSS coated Gold Nanopillar Micro-electrodes for Neural Interfaces. Taipeh, Taiwan
  • Maike Stern, Christoph Nick, Christiane Thielemann, 2014. A Novel LabVIEW based Multi-Channel Closed-Loop Stimulator. Reutlingen, Germany
  • Robert Bestel 2018. Simulation neuronaler Aktionspotentiale in Hinblick auf Zellform und Physiologie sowie deren Ableitung mittels extarzellulärer Mikroelektroden.
  • Florian Emmerich, Christiane Thielemann, 2011. Observation of Thermal Discharge in Nanopatterned Electrets by Kelvin-Probe-Microscopy. S. 149 — 150. ISBN 978-1-4577-1023-0. ISSN 2153-3253.
  • Simone Hufgard, Margot Mayer, Insa S. Schroeder, Christiane Thielemann, 2025. 3D compartmentilisation for analyzing functional long-range connectivity between brain regions.
  • Melanie Jungblut, Wolfgang Knoll, Christiane Thielemann, Mark Pottek, 2009. Triangular neuronal networks on microelectrode arrays: an approach to improve the properties of low-density networks for extracellular recording. In: Biomed Microdevices, 2009. 11(6), S. 1269 — 1278.
  • Andreas Daus, Robert Bestel, Christiane Thielemann, 2011. Spike Detection, Refinement And Interpretation Of Recordings In Three-Dimensional In Vitro Systems.
  • Margot Mayer 2017. Einfluss ionisierender Strahlung auf die elektrophysiologischen Eigenschaften sich entwickelnder neuronaler Netzwerke. Fulltext
  • Berit Silke Körbitzer, Peter Krauß, Jörg Schneider, Christiane Thielemann, 2016. Characterization Of Graphene-Coated Microelectrode Arrays For Recording And Stimulation Of Neuronal Cells.
  • Margot Mayer, Onetsine Arrizabalaga, Sylvia Ritter, Christiane Thielemann, 2015. Human embryonic stem cell derived neurospheres form functional networks on microelectrode arrays.
  • Johannes Frieß, Anja Heselich, Sylvia Ritter, Angelina Haber, Nicole Kaiser, Paul Layer, Christiane Thielemann, 2015. Electrophysiologic and cellular characteristics of cardiomyocytes after X-ray irradiation. In: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2015(777), S. 1 — 10.
  • Alexander Helm, Simon Frank, Johannes Frieß, Christiane Thielemann, Marco Durante, Sylvia Ritter, 2013. Purified cultures of mouse embryonic stem cell-derived cardiomyocytes of electrophysiological studies with ionizing radiation.
  • Miriam Materna, Alexander Helm, Petra Hessel, Johannes Frieß, Christiane Thielemann, Diana Pignalosa, Werner Mäntele, Marco Durante, Sylvia Ritter, 2012. First electrophysiological studies on mouse embryonic stem cell-derived cardiomyocytes.
  • Christoph Nick, Ravi Joshi, Helmut Schlaak, Jörg Schneider, Christiane Thielemann, 2011. Multi electrode array with carbon nanotube electrodes for the extra-cellular detection of action potentials.
  • Andreas Daus, Michael Goldhammer, Ulrich Bochtler, Christiane Thielemann, 2010. A new approach for the investigation of long-term effects of RF radiation on cells.
  • Christoph Nick 2015. Mikrointegrierte Nanostrukturen mit hohem Aspektverhältnis als neuronale Schnittstelle. Fulltext
  • Tim Köhler 2019. Auswirkungen elektromagnetischer Strahlung auf die elektrophysiologischen Eigenschaften neuronaler und kardialer Zellnetzwerke. Fulltext
  • Manuel Ciba 2021. Synchrony Measurement and Connectivity Estimation of Parallel Spike Trains from in vitro Neuronal Networks. Abstract
  • Julia Obmann, Christopher Polt, Thomas Loose, Tim Asmus, Karlheinz Wienand, Christiane Thielemann, 2013. Novel Resistive Bioaffinity Sensor based on Ultra-Thin Gold Films.
  • Christiane Thielemann, Sylvia Ritter, Paul Layer, Johannes Frieß, Andreas Daus, Frederik Steger, Anja Heselich, 2011. Cellular effects of space radiation with relevance to cardiovascular diseases. S. 560.
  • Andreas Daus, Paul Layer, Christiane Thielemann, 2012. A spheroid-based biosensor for the label-free detection of drug-induced field potential alterations. In: Sensors and actuators B: Chemical. 165(1), S. 53 — 58.
  • Andreas Daus, Robert Bestel, Christiane Thielemann, 2014. A multivariate spike-detection algorithm to assess activity patterns of three-dimensional in vitro models. S. 194 — 195. ISSN 2199-1596.
  • Stefan Oster, Andreas Daus, Michael Goldhammer, Ulrich Bochtler, Christiane Thielemann, 2013. A Flexible RF Exposure Setup for Long-term Electrophysiological Investigations on Biological Samples in Vitro.
  • Christoph Nick, Ravi Joshi, Jörg Schneider, Christiane Thielemann, 2012. Low Temperature Substrate Transfer Technique for 3D Vertically Aligned Carbon Nanotube Architectures. In: International Journal of Surface Science and Engineering. 6(3), S. 246 — 246.
  • Andreas Daus, Michael Goldhammer, Christiane Thielemann, 2010. Using three-dimensional cell culture systems on Microelectrode arrays for biosensing applications. S. 314 — 315. ISBN 978-3-938345-08-5.
  • Andreas Daus, Stefan Oster, Christian Erbes, Michael Goldhammer, Ulrich Bochtler, Christiane Thielemann, 2013. Electromagnetic exposure of neuronal networks on microelectrode arrays. S. 29 — 30.
  • Christoph Nick, Paul Lippert, Sebastian Quednau, Helmut Schlaak, Christiane Thielemann, 2014. Gold Nanopillar Microelectrodes on Low Temperature Curing Polyimide for the Interface with Electrogenic Cells. Doha, Qatar S. 55 — 58. ISBN 978-1-4799-4799-7.
  • Manuel Ciba, Andreas Bahmer, Christiane Thielemann, 2017. Application of spike train synchrony measure Spike‑contrast to quantify the effect of bicuculline on cortical networks grown on microelectrode arrays.
  • Christoph Nick, Robert Bestel, Frederik Steger, Christiane Thielemann, 2013. Spike Detection, Sorting and Propagation of Cell Signals Recorded with Extracellular Microelectrodes, Engineering in Medicine and Biology Society.
  • Frederik Steger, Johannes Frieß, Andreas Daus, Sylvia Ritter, Christiane Thielemann, 2012. Analysis of electrophysiological characteristics of cardiomyocytes following radiation exposure. S. 153. ISSN 2194-5519.
  • Caroline L. Alves, Lennart Wissel, Philipp Capetian, Christiane Thielemann, 2022. Functional connectivity and convolutional neural networks for automatic classification of EEG data. In: Clinical Neurophysiology. 2022(137), S. e37 — e47. Abstract
  • Johannes Frieß, Anja Heselich, Sylvia Ritter, Paul Layer, Christiane Thielemann, 2014. Combined effects of ionizing radiation and cardio-active drugs on human iPSC-derived cardiomyocytes.
  • Christoph Nick, Sebastian Quednau, Reza Sarwar, Helmut Schlaak, Christiane Thielemann, 2013. High Aspect Ratio Gold Nanopillars on Microelectrodes for Neural Interfaces. In: Microsystem Technologies Media. (20/10-11), S. 1849 — 1857. ISSN 0946-7076. Fulltext
  • Christoph Nick, Sebastian Quednau, Reza Sarwar, Christiane Thielemann, Helmut Schlaak, 2013. Fabrication of high aspect ratio gold nanopillars on microelectrodes for the interface with electrogenic cells. S. 212 — 213.
  • Manuel Ciba, Christiane Thielemann, 2018. Synchrony changes on different time-scales during in vitro neuronal network development. Fulltext
  • Jing Li, Christiane Thielemann, Ute Reuning, Diethelm Johannsmann, 2005. Monitoring of Integrin-Mediated Adhesion of Human Ovarian Cancer Cells to Model Protein surfaces by Quartz crystal Resonators: Evaluation in the Impedance Analysis Mode. In: Biosensors and Bioelectronics. S. 1333 — 1334.
  • Christoph Nick, Ravi Joshi, Jörg Schneider, Christiane Thielemann, 2012. Three-Dimensional Carbon Nanotube Electrodes for Extracellular Recording of Cardiac Myocytes. In: Biointerphases, 2012. S. 58. Abstract
  • Alexander Helm, Simon Frank, Johannes Frieß, Christiane Thielemann, Marco Durante, Sylvia Ritter, 2014. Electrophysiological response of mouse embryonic stem cell-derived cardiomyocytes after X-ray and C-ion exposure.
  • Margot Mayer, Benedikt Müller, Suzanne Kadereit, Sylvia Ritter, Christiane Thielemann, 2014. Human neurospheres on microelectrode arrays: a model to investigate ionizing radiation effects on neuronal network communication.
  • Christiane Thielemann, Sylvia Ritter, Paul Layer, Johannes Frieß, Andreas Daus, Frederik Steger, Anja Heselich, 2012. IBER10 - Cellular effects of space radiation with relevance to cardiovascular diseases. Aberdeen, Schottland, UK
  • Johannes Frieß, Sylvia Ritter, Andreas Daus, Paul Layer, Christiane Thielemann, Anja Heselich, 2013. Electrophysiologic and Molecular Characteristics of Cardiomyocytes after Heavy Ion Irradiation in the frame of the ESA IBER-10 Program.
  • Christoph Nick, Andreas Daus, Robert Bestel, Michael Goldhammer, Frederik Steger, Christiane Thielemann, 2013. DrCell - a software tool for the analysis of cell signals recorded with extracellular microelectrodes. In: Signal processing: an international journal (SPIJ). 7(2), S. 96 — 109. Fulltext
  • Manuel Ciba, Margot Mayer, Christiane Thielemann, 2019. Experimental setup to investigate the effect of psychedelics on in vitro neuronal networks. Abstract Fulltext
  • Mario Kupnik, Christiane Thielemann, 2017. In vitro platform for acoustic and electrophysiological investigations of ultrasound stimulation. In: Brain Stimulation. 10(2), S. 501. Abstract
  • Oktay Yilmazoglu, Shihab Al-Daffaie, Hans Hartnagel, Ravi Joshi, Sandeep Yadav, Jörg Schneider, Christoph Nick, Christiane Thielemann, 2012. CNT photocathodes based on GaAs high-frequency photoswitches. Abstract
  • Dennis Flachs, Florian Emmerich, Gian-Luca Roth, Ralf Hellmann, Christiane Thielemann, 2019. Laser-bonding of FEP/FEP interfaces for a flexiblemanufacturing process of ferroelectrets. In: Journal of Physics: Conference Series. 1407(012107), S. 1 — 5. Abstract
  • Nenad Krstić, Jens Jüttner, Lars Giegerich, Margot Mayer, Monika Knuth, Achim Müller, Christiane Thielemann, 2023. 3D printed biosensor for continuous glucose measurement in cell cultures. In: Annals of 3D Printed Medicine. ISSN 2666-9641.
  • Caroline L. Alves, Aruane M. Pineda, Kirstin Roster, Christiane Thielemann, Francisco A. Rodrigues, 2022. EEG functional connectivity and deep learning for automatic diagnosis of brain disorders: Alzheimer’s disease and schizophrenia. In: Journal of Physics: complexity. 2022(3), S. 1 — 13. Abstract
  • Christoph Nick, Christiane Thielemann, Ravi Joshi, Jörg Schneider, 2011. Niedrigtemperatur-Transfer von vertikal ausgerichteten Kohlenstoff Nanoröhren auf Mikrostrukturen. Abstract
  • Nathaniel J. Szewczyk, Monica Monici, Christiane Thielemann, 2024. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems? In: npj Microgravity. 2024(10), S. 1 — 5. Abstract
  • Dennis Flachs, Johannes Etzel, Margot Mayer, Frederic Harbecke, Stefan Belle, Tim Rickmeyer, Christiane Thielemann, 2022. Characterization of electrically conductive, printable ink based on alginate hydrogel and graphene nanoplatelets. In: Biomedical Engineering Advances. 2022(4), S. 1 — 2. Abstract
  • Dennis Flachs, Tim Köhler, Christiane Thielemann, 2018. Transparent poly(3,4-ethylenedioxythiophene)-based microelectrodes for extracellular recording. In: Biointerphases. 2018(13:041008), S. 1 — 1. Abstract
  • Margot Mayer, Onetsine Arrizabalaga, Insa Schröder, Sylvia Ritter, Christiane Thielemann, 2018. Human Embryonic Stem Cell Derived Neurospheres – 2D and 3D Cell Culture in one sample. Abstract Fulltext
  • Christoph Nick, Sandeep Yadav, Ravi Joshi, Jörg Schneider, Christiane Thielemann, 2015. A three-dimensional microelectrode array composed of vertically aligned ultra-dense carbon nanotube networks. In: Applied Physics Letters. 2015(107), S. 1 — 1. Abstract
  • Caroline L. Alves, Francisco A. Rodrigues, Loriz Francisco Sallum, Thaise Toutain, Joel Augusto Moura Porto, Patricia de Carvalho Aguiar, Christiane Thielemann, Michael Möckel, 2024. Multiclass classification of Autism Spectrum Disorder, attention deficit hyperactivity disorder, and typically developed individuals using fMRI functional connectivity analysis. In: plos one. 2024(19(10)), S. 1 — 35. Abstract Fulltext
  • Robert Bestel, Revathi Appali, Ursula van Rienen, Christiane Thielemann, 2017. Effect of Morphologic Features of Neurons on the Extracellular Electric Potential: A Simulation Study Using Cable Theory and Electro-Quasi-Static Equations. In: Neural Computation. 2017(29), S. 2955 — 2978. Abstract
  • Monica Monici, Christiane Thielemann, 2023. How do gravity alterations affect animal and human systems at a cellular/tissue level? In: nature npj Microgravity. 2023(9/84), S. 1 — 9. Abstract
  • Loriz Francisco Sallum, Caroline L. Alves, Christiane Thielemann, Francisco A. Rodrigues, 2024. Revealing patterns in major depressive disorder with machine learning and networks. In: medrxiv. 2024(1), S. 1 — 17. Abstract
  • Jan Hölter, Tim Rickmeyer, Christiane Thielemann, 2025. CellRex: Software platform for managing biological cell data. In: SoftwareX. ISSN 2352-7110. Abstract
  • Berit Silke Körbitzer, Peter Krauß, Stefan Belle, Jörg Schneider, Christiane Thielemann, 2019. Electrochemical Characterization of Graphene Microelectrodes for Biological Applications. In: ChemNanoMat. 2019(5:4), S. 427 — 435. Abstract
  • Margot Mayer, Onetsine Arrizabalaga, Sylvia Ritter, Christiane Thielemann, 2016. Human Embryonic Stem Cell Derived Neurospheres - A Novel Three Dimensional Model For Neurotoxicological Studies. Abstract
  • Christoph Nick, Helmut Schlaak, Christiane Thielemann, 2015. Simulation and Measurement of Neuroelectrodes' Characteristics with Integrated High Aspect Ratio Nano Structures. In: AIMS Journal. 2015(2), S. 189 — 202. Abstract
  • Christiane Thielemann, Nenad Krstić, Jens Jüttner, Lars Giegerich, Margot Mayer, Monika Knuth, Achim Müller, 2023. 3D printed biosensor for continuous glucose measurement in cell cultures. In: Annals of 3D Printed Medicine. 2023(-). Abstract
  • Davis Trent, Christiane Thielemann, Monica Monici, 2024. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms? In: npj Microgravity. 2014(10 / 16), S. 1 — 7. Abstract Fulltext
  • Stefan Oster, Andreas Daus, Christian Erbes, Michael Goldhammer, Ulrich Bochtler, Christiane Thielemann, 2016. Long‐term electromagnetic exposure of developing neuronal networks: A flexible experimental setup. In: Bioelectromagnetics. 2016(37), S. 264 — 278. Abstract
  • Florian Emmerich, Christiane Thielemann, 2015. Patterning of PMMA by gold-nanoparticle initiated localized decomposition. Abstract
  • Dennis Flachs, Levin Bernhard, Christiane Thielemann, 2024. Fully 3D-Printed Rotational Energy Harvester Based On Bipolar Charged PLA Electrets. IEEE. ISBN 979-8-3503-8020-0. Abstract Fulltext
  • Florian Lieb, Hans-Georg Stark, Christiane Thielemann, 2017. A stationary wavelet transform and a time-frequency based spike detection algorithm for extracellular recorded data. In: Journal of Neural Engineering. 2017(14), S. 1 — 13. Abstract
  • Stefano De Blasi, Manuel Ciba, Andreas Bahmer, Christiane Thielemann, 2019. Total spiking probability edges: A cross-correlation based method for effective connectivity estimation of cortical spiking neurons. In: Journal of Neuroscience Methods. 312(312), S. 169 — 181. Abstract
  • Robert Samhaber, Manuel Schottdorf, Ahmed El Hady, Kai Bröking, Andreas Daus, Christiane Thielemann, Walter Stühmer, Fred Wolf, 2016. Growing neuronal islands on multi-electrode arrays using an accurate positioning-μCP device. In: Journal of Neuroscience Methods. 2016(257), S. 194 — 203. Abstract
  • Caroline L. Alves, Thaise Toutain, Patricia de Carvalho Aguiar, Aruane M. Pineda, Kirstin Roster, Christiane Thielemann, Joel Augusto Moura Porto, Francisco A. Rodrigues, 2023. Diagnosis of autism spectrum disorder based on functional brain networks and machine learning. In: Scientific Reports. 2023(13/8072), S. 1 — 20. Abstract Fulltext
  • Anja Heselich, Johannes Frieß, Sylvia Ritter, Naja Benz, Paul Layer, Christiane Thielemann, 2018. High LET radiation shows no major cellular and functional effects on primary cardiomyocytes in vitro. In: Life Sciences in Space Research. 2018(16), S. 93 — 100. Abstract
  • Manuel Ciba, Takuya Isomura, Yasuhiko Jimbo, Andreas Bahmer, Christiane Thielemann, 2017. Spike-contrast: A novel time scale independent and multivariate measure of spike train synchrony. In: Journal of Neuroscience Methods. 2018(293), S. 136 — 143. Abstract
  • Christoph Nick, Christina Hock, Florian Emmerich, Stefan Belle, Christiane Thielemann, Tim Asmus, Thomas Loose, Karlheinz Wienand, 2015. Ultrathin gold as sensor platform for biomolecules. Abstract
  • Loriz Francisco Sallum, Caroline L. Alves, Thaise Graziele L de O Toutain, Joel Augusto Moura Porto, Christiane Thielemann, Francisco A. Rodrigues, 2025. Revealing patterns in major depressive disorder with machine learning and networks. In: Chaos, Solitons & Fractals. ISSN 0960-0779. Abstract
  • Manuel Ciba, Marc Petzold, Caroline L. Alves, Francisco A. Rodrigues, Yasuhiko Jimbo, Christiane Thielemann, 2025. Machine learning and complex network analysis of drug effects on neuronal microelectrode biosensor data. In: Scientific Reports. 15(1). ISSN 2045-2322. Abstract